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When symptoms occur, they typically relate to underlying conditions such as liver disease, kidney dysfunction, or haematological disorders that cause the elevation, rather than the high B12 itself

At initial doses of 1 to 2mg weekly, most researchers report mild appetite suppression within the first week, with effects becoming more pronounced during dose escalation

BMO's Seigerman said he's not convinced that the upcoming trial "is going to change the narrative around CagriSema." Novo also expects to begin a phase three trial investigating a higher dose of CagriSema in the second half of 2026

2025 May;46(5):422-436